Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936

Authors
Sum, PE Petersen, P
Citation
Pe. Sum et P. Petersen, Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936, BIOORG MED, 9(10), 1999, pp. 1459-1462
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
10
Year of publication
1999
Pages
1459 - 1462
Database
ISI
SICI code
0960-894X(19990517)9:10<1459:SASRON>2.0.ZU;2-H
Abstract
A number of new glycylcyclines were synthesized for structure-activity rela tionship study. Many of the derivatives exhibit potent, broad spectrum anti bacterial activity against both tetracycline susceptible and resistant orga nisms. GAR-936 (TBG-MINO) shows better activity than the previously reporte d DMG-MINO and DMG-DMDOT. (C) 1999 Elsevier Science Ltd. All rights reserve d.