A case of epileptic negative myoclonus: therapeutic considerations

This study presents a patient with epileptic negative myoclonus who showed interictal focal epileptic discharges in the centrotemporal region. The pat ient's seizures were exacerbated by carbamazepine, zonisamide, and valproat e, but completely controlled by ethosuximide, and were suggested to have so me relation with thalamocortical oscillation mechanisms. Ethosuximide is su pposed to be a drug of worth to try to use in epileptic negative myoclonus patients with centrotemporal spike fuci. (C) 1999 Elsevier Science B.V. All rights reserved.