Serological testing in screening for adult celiac disease

Assays for celiac related antibodies an becoming widely available, and the present review aims to clarify the use of these investigations in the diagn osis of management of and screening for adult celiac disease. The sensitivi ties and specificities of various antibody tests are discussed, along with their clinical use as an adjunct to small bowel biopsy, and as a first-line investigation for patients with atypical symptoms of celiac disease or pat ients at high risk of developing sprue.