Loss of chromosome 13 is the most frequent genomic imbalance in malignant fibrous histiocytomas - A comparative genomic hybridization analysis of a series of 30 cases
A. Mairal et al., Loss of chromosome 13 is the most frequent genomic imbalance in malignant fibrous histiocytomas - A comparative genomic hybridization analysis of a series of 30 cases, CANC GENET, 111(2), 1999, pp. 134-138
Regional chromosome localizations of DNA copy number imbalances were studie
d by comparative genomic hybridization in 30 malignant fibrous histiocytoma
s: 13 primary tumors (2 myxoid, 9 storiform pleomorphic, and 2 with more un
differentiated phenotype) and 17 local recurrences (2 myxoid, 11 storiform
pleomorphic, and 4 with more undifferentiated phenotype). Abnormal comparat
ive genomic hybridization (CGH) profiles were observed in 25 tumors (83%).
The most frequent gains (ratio >1.2) corresponded, by order of frequency, t
o entire Xp, and bands 1q21, 19q13.1, 19p13, 5p13-p14, 1p31, 17p, 18p, 20q,
1p35, 17q23, and 22q12. High levels of gains (ratio >1.5) rr ere recurrent
ly detected for Xp (10 cases), and in bands 1q21-q22 (8 cases), 3q27 (4 cas
es), 5p13-p14 (3 cases), 13q32-q34 (3 cases), 15q22-q26 (3 cases), and 17p1
1-p12 (3 cases). Losses of 13q12-q14 or 13q21 were observed in a large prop
ortion of tumors (17 cases), suggesting that a gene localized in this regio
n could act as a tumor suppressor gene. Losses of 11q23, 2q32, 11p13, 10p,
1q4, 9p2, 16q12, 4q3, 10q25, 3p23, 2p24, and 12p were also recurrently obse
rved. Taken together these results provide an overview of chromosome imbala
nces present in MFH, which could be of use for diagnostic purposes. They po
int to various chromosome regions which may harbor genes important for mali
gnant fibrous histiocytomas (MFH) oncogenesis and progression. (C) Elsevier
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