Cytogenetic investigation of canine lipomas

Akin to humans, lipomas are common in the dog as well; however, until now t here were no reports of cytogenetic investigations on these tumors in the c anine. We report our results of cytogenetic investigations on a series of t en canine lipomas. Clonal aberrations were observed in seven cases. In one case a trisomy 27 was evident; in another case a trisomy 13 was present in addition to a marker chromosome. A third lipoma showed a fusion of chromoso mes 2 and 13. Three cases showed one derivative chromosome each (der(X), de r(7), and der(4)), and one case had two derivative chromosomes (der(X) plus der(4)). In the two cases with derivative chromosomes 4, the same region ( 4q31) was affected. It is tempting to speculate that this region might harb or a gene associated with tumor development. The results are compared to th e cytogenetic situation in human lipomas. (C) Elsevier Science me., 1999. A ll rights reserved.