Although individuals with schizophrenia often have other psychiatric condit
ions, such as panic disorder; less treatment attention is typically focused
on this problem. Although established, efficacious cognitive behavioral tr
eatments (CBT) exist, rarely have these interventions been used with indivi
duals with schizophrenia. Our objective is to further improve the effective
ness (clinical utility) of an empirically validated treatment for panic dis
order Specific strategies are discussed regarding the modification of the t
reatment environment, the role of other providers, the establishment of rap
port and the therapist-patient relationship when utilizing CBT for panic di
sorder with patients with schizophrenia. Furthermore, issues related to cul
tural differences, trauma history, and ethics are explored. Additionally, t
he treatment approach is outlined and the limitations of a standardized tre
atment intervention are discussed. Finally, a case example of a client with
schizophrenia and panic disorder treated with a modified version of an emp
irically validated, cognitive behavioral protocol for panic disorder is off
ered to illustrate the points.