Lack of genetic associations of alpha-1-antichymotrypsin polymorphism withAlzheimer-type neuropathological changes or sporadic Alzheimer's disease

To elucidate the influence of the al-antichymotrypsin (ACT) polymorphism on Alzheimer-type neuropathological changes and the development of sporadic A lzheimer's disease (AD), we studied the relationship between the ACT polymo rphism and the severity of Alzheimer-type neuropathological changes in the brains from AD patients and nondemented subjects. There was no association of the ACT polymorphism with Alzheimer-type neuropathological changes in AD or nondemented individuals. ACT polymorphism was not associated with the d evelopment of AD, These results remained nonsignificant when the ACT genoty pe groups were divided into subgroups according to the apolipoprotein E (Ap oE) epsilon 4 status. Our study shows that the ACT polymorphism has no effe ct on Alzheimer-type neuropathological changes or the development of AD, ei ther alone or in combination with ApoE epsilon 4.