Amelanotic melanomas comprise only 2% of melanomas and are commonly a diffi
cult clinical diagnosis, due to the lack of melanin pigment typically found
in melanomas. Even rarer is the amelanotic lentigo maligna, which may have
an unusual clinical presentation, such as erythema, pruritus, or edema. Bi
opsy is the key to diagnosis. Multiple therapies for amelanotic lentigo mal
ignas have been tried, but excision, with margin control (Mohs micrographic
surgery-frozen or paraffin sections), remains the treatment of choice.