Two subjects with ictal hemiparesis are described. Both children presented
with evolving paresis associated with seizure activity. Structural neuroima
ging remained consistently normal, although EEG demonstrated slow-wave acti
vity, and SPECT scanning in one child showed perfusion asymmetry. Both chil
dren had resolution of the hemiparesis when seizure activity was adequately
controlled. The historically proposed pathophysiology of ictal hemiparesis
is that of inhibition of the somatosensory and motor areas of the cortex,
The presence of an evolving hemiparesis and seizure activity associated wit
h normal neuroimaging should prompt consideration of ictal hemiparesis, Con
firmation of this rare diagnosis can only be made when seizure control lead
s to resolution of the paresis.