Combined ligation and sclerotherapy versus ligation alone for eradication of bleeding esophageal varices: A randomized and prospective trial

Background and Study Aims: A number of trials have been reported in which a combination of ligation and sclerotherapy was compared with ligation alone , or with sclerotherapy alone. The present trial was carried out to assess whether the combined therapy might achieve more rapid eradication of bleedi ng esophageal varices. Patients and Methods: One hundred and three patients with either active ble eding or stigma of recent bleeding from esophageal varices were randomly as signed to receive ligation plus sclerotherapy, or ligation alone. Ligation was performed with the technique introduced by Stiegmann, Sclerotherapy was carried out using low-volume (1 ml) 1% aethoxysclerol, which was injected into varices proximal to each ligature. Further treatment sessions were hel d seven days later, and then at two-week intervals, until eradication of th e varices was achieved. Endoscopic follow-up examinations were carried out at three-month intervals, or immediately if there tvas any recurrent bleedi ng. The mean follow-up period was 14 months. Results: There were no significant differences between the groups of patien ts compared with regard to the number of sessions required to eradicate the varices (2.4 +/- 0.7 in the combined group, and 2.3 +/- 0.7 in the ligatio n group; p > 0.05). No significant differences were found between the group s with regard to recurrent bleeding (Fp = 2.882; p > 0.05). Three cases of recurrent bleeding (6%) from treatment-induced ulcers and two cases of recu rrent bleeding (4%) from duodenal ulcers were observed with the combined th erapy and ligation, respectively, No significant differences in the mortali ty were found between the groups (Fp = 1.145; p > 0.05). Two percent of pat ients in the ligation group died due to bacterial peritonitis. Conclusion: Since ligation combined with low-volume sclerotherapy did not r educe the time required for variceal eradication, it can be concluded that the combined therapy is not superior to ligation alone. This mode of endosc opic therapy for the treatment of bleeding esophageal varices is therefore not recommended.