Jm. Lapointe et al., INTRAVASCULAR MALIGNANT T-CELL LYMPHOMA (MALIGNANT ANGIOENDOTHELIOMATOSIS) IN A CAT, Veterinary pathology, 34(3), 1997, pp. 247-250
A 7-year-old spayed female Siamese cat was presented with a 7-day hist
ory of ataxia, circling to the right, and involuntary micturition and
defecation. Cerebrospinal fluid analysis showed increased protein cont
ent and relative eosinophilia. At necropsy, there was flattening of th
e cerebral cortical gyri of the right frontal and parietal lobes, and
both kidneys had multiple wedge-shaped cortical indentations. Histolog
ically, the cerebral cortex contained several extensive malacic foci,
and the kidneys had multifocal parenchymal degeneration and atrophy. T
here was multifocal partial to complete thrombosis of renal interlobar
arteries and of the right middle cerebral artery and meningeal branch
es; these thrombi contained large anaplastic round cells, which often
invaded the arterial wall. Many smaller vessels within the kidneys and
brain were occluded with clusters of similar cells, without thrombosi
s or vascular wall invasion. The neoplastic round cells had immunohist
ochemical staining properties of T lymphocytes.