Three cases of placental polyps not responding to conventional medical and
surgical treatment are presented. In all three cases, hCG in serum was nega
tive but despite this a single injection of methotrexate successfully treat
ed the condition. It is suggested that methotrexate acts not only on dividi
ng trophoblastic cells but also has other effects. (C) 1999 Elsevier Scienc
e Ireland Ltd. All rights reserved.