Small for gestational age infant in association with maternal prothrombin gene variant (nt 20210A)

Authors
Verspyck, E Le Cam-Duchez, V Gravier, A Descargues, G Marpeau, L Borg, JY
Citation
E. Verspyck et al., Small for gestational age infant in association with maternal prothrombin gene variant (nt 20210A), EUR J OB GY, 83(2), 1999, pp. 143-144
Citations number
11
Categorie Soggetti
Reproductive Medicine
Journal title
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
ISSN journal
03012115 → ACNP
Volume
83
Issue
2
Year of publication
1999
Pages
143 - 144
Database
ISI
SICI code
0301-2115(199904)83:2<143:SFGAII>2.0.ZU;2-M
Abstract
Most of disproportionate infants born small for gestational age (SGA) have an history of placental dysfunction with no explained cause. We report a ca se of an unexplained SGA infant with placental infarctions and thrombosis. Maternal thrombophilic disorder tests revealed that the patient was heteroz ygous for the A20210 prothrombin gene variant a newly identified thrombotic risk factor. It may be suggest that prothrombin gene variant, as factor V Leiden, could be a genetic risk factor for placental insufficiency. (C) 199 9 Elsevier Science Ireland Ltd. All rights reserved.