Intake of long chain w3 polyunsaturated fatty acids during pregnancy and the influence of levels in the mother on newborn levels

Objective. To assess the relationship between the free intake of long chain w3 polyunsaturated fatty acid (w3 LCP) during pregnancy and the levels in the mother with the levels in the neonate. Design. Cross-sectional study. S etting. University hospital. Subjects. One hundred and sixty-two mother-neo nate pairs from normal at-term pregnancies. Main outcome measure, Dietetic interview in order to assess the w3 LCP intake. w3 LCPs were analyzed by ca pillary gas chromatography in plasma (expressed as percentage and as total amount) and in erythrocyte phospholipids (expressed as percentage) from mot hers and neonates. Results. The w3 LCP intake assessed by the dietetic inte rview was significantly correlated with w3 LCP levels in the plasma of both mothers and neonates. The levels of w3 LCPs in mothers and neonates were s ignificantly correlated both in plasma fatty acids (expressed both as a per centage and absolute values) and in erythrocyte phospholipids (in percentag e) (r = 0.49-0.22). Conclusion. In an apparently well-nourished population the w3 LCP levels of the newborn infants are clearly influenced by those of their mothers. The higher the levels in mothers, the higher those in the n eonates, The w3 LCP intake assessed by an interview also showed a significa nt influence, but to a lesser extent. (C) 1999 Elsevier Science Ireland Ltd . All rights reserved.