Pelvic malignant mixed mesodermal tumor of uncertain origin: a case report

Extra-uterine, and especially extragenital, malignant mixed mesodermal tumo rs (MMMT) are very rare. A large intrapelvic tumor resected from a 56-year- old woman was investigated with morphological and immunohistochemical metho ds. A large, soft and fragile tumor was located in the pelvic space. The tu mor showed high cellularity and was biphasic; it consisted of an admixture of adenocarcinoma and various kinds of sarcomas. The latter were comprised of high-grade endometrial stromal sarcoma, pleomorphic sarcoma, and chondro sarcoma. The pleomorphic sarcoma showed a storiform pattern. The periodic a cid-Schiff-positive eosinophilic hyaline droplets and globules in multinucl eated giant cells revealed a typical ring-like or peripheral staining for a lpha-1-antitrypsin and alpha-1 antichymotrypsin. We considered this case to be pelvic MMMT of uncertain origin, heterologous type. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.