Constrictive bronchiolitis obliterans and paraneoplastic pemphigus

Constrictive bronchiolitis obliterans is rare, and the pathogenesis of the disease often remains unknown. This study reports on the case of a 38 yr-ol d female with constrictive bronchiolitis obliterans and paraneoplastic pemp higus associated with malignant lymphoma. The patient developed progressive obstructive lung disease. The chest radiograph shelved almost normal lungs . Paraneoplastic pemphigus is a newly described syndrome in which patients have autoantibodies binding to some epithelia, including in the respiratory tract. The disease develops in association with non-Hodgkin's lymphomas or other malignant neoplasms. The case presented here suggests that constrict ive bronchiolitis obliterans associated with paraneoplastic pemphigus may b e one of the facets of autoimmune responses in this context.