New agents for chemoprevention of prostate cancer

The magnitude of the problem of prostate cancer, and the failure of convent ional chemotherapy and surgery to effect a marked diminution in the total n umber of deaths from this disease, now indicate that chemoprevention of pro static carcinogenesis must be seriously considered. We describe the develop ment of a new system for quantitating the process of prostatic carcinogenes is in an experimental animal, and the use of this system to demonstrate tha t the retinoid, 4-hydroxyphenylretinamide, the deltanoid, Ro24-5531, and th e estrogen analog, tamoxifen, all are effective agents for prevention of ex perimental prostate cancer.