IgG antibodies to Lewis type 2 antigen in serum of H-pylori-infected and noninfected blood donors of different Lewis(a,b) blood-group phenotype

Authors
Kurtenkov, O Klaamas, K Miljukhina, L Shljapnikova, L Ellamaa, M Bovin, N Wadstrom, T
Citation
O. Kurtenkov et al., IgG antibodies to Lewis type 2 antigen in serum of H-pylori-infected and noninfected blood donors of different Lewis(a,b) blood-group phenotype, FEMS IM MED, 24(2), 1999, pp. 227-232
Citations number
16
Categorie Soggetti
Immunology
Journal title
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
ISSN journal
09288244 → ACNP
Volume
24
Issue
2
Year of publication
1999
Pages
227 - 232
Database
ISI
SICI code
0928-8244(199906)24:2<227:IATLT2>2.0.ZU;2-J
Abstract
Individuals of the Le(b+)/secretor phenotype revealed a stronger natural im mune response to Le(x) and Le(y) epitopes irrespective of Helicobacter pylo ri serologic status. In contrast, H. pylori-infected Le(b-) type individual s showed a significantly higher proportion of strong responders to Le(x) an tigen compared with the H. pylori-uninfected subgroup. The data suggest tha t the immune response to Lewis type 2 determinants is related to both the H . pylori serologic status and the Le(a,b) phenotype of the host. (C) 1999 F ederation of European Microbiological Societies. Published by Elsevier Scie nce B.V. All rights reserved.