BACKGROUND/AIMS: There are few studies about gastrointestinal abnormalities
in patients with juvenile rheumatoid arthritis - probably due to the fact
that this association is not frequently recognized. The aim of our study wa
s to observe the prevalence of endoscopic gastroduodenal lesions in these p
atients.
METHODOLOGY: Fourteen patients with juvenile rheumatoid arthritis, all of t
hem using non-steroidal anti-inflammatory drugs associated or not with meth
otrexate, were assessed clinically and by endoscopy. Gastric antrum biopsy
and Helicobacter pylori search were also performed.
RESULTS: The mean age of the patients was 10.6 years (7 boys). Abdominal pa
in was observed in 27% of them. Macroscopic endoscopic lesions were found i
n 43% and infection by Helicobacter pylori in 57%. The correlation between
anemia and endoscopic abnormalities was statistically significant (p<0.05).
CONCLUSIONS: Our data show that patients with juvenile rheumatoid arthritis
have considerable susceptibility to gastroduodenal lesions, especially if
they are using any drug association and present anemia.