Effect of non-steroidal anti-inflammatory drugs on gastric and duodenal prostaglandin concentrations in patients with Helicobacter pylori infection

BACKGROUND/AIMS: Both Helicobacter pylori and non-steroidal anti-inflammato ry drugs are reported to affect gastroduodenal prostaglandin synthesis. How ever, their influence on gastric mucosal prostaglandins remains-unclear. Th e aim of this study was to investigate the influence of nonsteroidal anti-i nflammatory drugs on mucosal prostaglandin synthesis in patients with Helic obacter pylori infection. METHODOLOGY: We enrolled 87 Helicobacter pylori-infected patients in this s tudy (gastric ulcer: 33, duodenal ulcer: 41, and non-ulcer dyspepsia: 13). Of them, 27 patients received non-steroidal antiinflammatory drugs; Endosco py was performed and biospy specimens from gastric body, antrum and duodena l bulb were assessed for Helicobacter pylori and prostaglandin concentratio n. RESULTS: A significantly lower mucosal prostaglandin E-2 level at gastric b ody (142.2 +/- 28.1 ng/mg vs. 222.0 +/- 12.4 ng/mg,mean +/- SEM) and antrum (131.3+/-26.4 ng/mg vs. 226.0 +/- 19.0 ng/mg) was noted in Helicobacter pyl ori-infected gastric ulcer patients with non-steroidal anti-inflammatory dr ugs ingestion than in that of patients without non steroidal anti-inflammat ory drugs ingestion (p<0.05). Using a multivariate analysis, we found that non-steroidal anti-inflammatory drug was an independent variable affecting gastric and duodenal mucosal prostaglandin Ee synthesis inpatients with Hel icobacter pylori-infected gastric ulcer. CONCLUSIONS: Non-steroidal anti-inflammatory drugs decrease gastroduodenal mucosal prostaglandin E-2 synthesis in gastric ulcer patients with Helicoba cter pylori infection.