Novel synthetic transformations of 5-(omega-chloroalkanoyl)-1,3-dimethylbarbituric acids

Authors
Strekowski, L Ismail, MA Zoorob, HH
Citation
L. Strekowski et al., Novel synthetic transformations of 5-(omega-chloroalkanoyl)-1,3-dimethylbarbituric acids, HETEROCYC C, 5(2), 1999, pp. 107-110
Citations number
3
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLIC COMMUNICATIONS
ISSN journal
07930283 → ACNP
Volume
5
Issue
2
Year of publication
1999
Pages
107 - 110
Database
ISI
SICI code
0793-0283(1999)5:2<107:NSTO5>2.0.ZU;2-T
Abstract
The treatment of 5-(4-chlorobutanoyl)-1,3-dimethylbarbituric acid (1) with K2CO3 furnishes a 5-(tetrahydrofuran-2-ylidene)barbituric acid derivative 2 . A similar reaction of 5-chloroacetyl-1,3-dimethylbarbituric acid (4) with Et3N yields a furanouracil 5. Synthetic transformations of 2 and 5 to 5-(o mega-heteroarylalkanoyl)-1,3-dimethylbarbituric acids and synthesis of othe r furanouracils from 5 are described.