Bacitracin versus mupirocin for Staphylococcus aureus nasal colonization

Authors
Soto, NE Vaghjimal, A Stahl-Avicolli, A Protic, JR Lutwick, LI Chapnick, EK
Citation
Ne. Soto et al., Bacitracin versus mupirocin for Staphylococcus aureus nasal colonization, INFECT CONT, 20(5), 1999, pp. 351-353
Citations number
10
Categorie Soggetti
Envirnomentale Medicine & Public Health
Journal title
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
ISSN journal
0899823X → ACNP
Volume
20
Issue
5
Year of publication
1999
Pages
351 - 353
Database
ISI
SICI code
0899-823X(199905)20:5<351:BVMFSA>2.0.ZU;2-6
Abstract
We performed a randomized prospective study of 5-day treatment with topical mupirocin or bacitracin for the elimination of Staphylococcus aureus nasal colonization in healthcare workers (HCWs). Nasal cultures were obtained fr om 141 HCWs, 37 (26%) of whom showed S aureus. After 72 to 96 hours of trea tment, the organism was eradicated in 15 (94%) of 16 by mupirocin and in 8 (44%) of 18 by bacitracin (P=.0031). Similar efficacy was demonstrated at 3 0 days. Mupirocin may be more effective than bacitracin for eradication of S aureus in healthy HCWs.