Antiendotoxin strategies

Endotoxin is a potent stimulator of the inflammatory response and is believ ed to initiate the pathology in Gram-negative sepsis. Agents are being deve loped that bind and neutralize or block the effects of endotoxin, with the goal of improving outcome in the treatment of sepsis. Strategies discussed in this article include anti-LPS antibodies, LPS binding proteins and lipop roteins, poly myxin B conjugates, Lipid A analogues, and extracorporeal tec hniques for endotoxin removal.