Although adhesion molecules present on circulating neutrophils and endothel
ial cells are essential for normal host defense, generalized activation of
these molecules has been implicated in the inflammatory tissue injury occur
ring during sepsis and septic shack. A review of both preclinical and clini
cal studies suggests, however, that although these molecules mediate tissue
injury related to a variety of microbial and host inflammatory mediators,
their predominant role during sepsis with infection is a protective one.