Neutrophil and endothelial cell interactions in sepsis - The role of adhesion molecules

Citation
C. Parent et Pq. Eichacker, Neutrophil and endothelial cell interactions in sepsis - The role of adhesion molecules, INF DIS CL, 13(2), 1999, pp. 427
Citations number
205
Categorie Soggetti
Clinical Immunolgy & Infectious Disease
Journal title
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
ISSN journal
08915520 → ACNP
Volume
13
Issue
2
Year of publication
1999
Database
ISI
SICI code
0891-5520(199906)13:2<427:NAECII>2.0.ZU;2-H
Abstract
Although adhesion molecules present on circulating neutrophils and endothel ial cells are essential for normal host defense, generalized activation of these molecules has been implicated in the inflammatory tissue injury occur ring during sepsis and septic shack. A review of both preclinical and clini cal studies suggests, however, that although these molecules mediate tissue injury related to a variety of microbial and host inflammatory mediators, their predominant role during sepsis with infection is a protective one.