Antiviral efficacy of disinfectant solution MRI-1

Disinfectant MRI-1 was prepared by dissolution of non-ionic and ionic deter gent in ethanol. The disinfectant inactivated extracellular and intracellul ar enveloped and non-enveloped viruses including herpes viruses, influenza A and human immunodeficiency disease virus in suspension or on surfaces by pre-exposure or post-exposure to the disinfectant; in addition, cells were disabled as potential hosts for viral infection using concentrations of MRI -I which were 50-fold less than the operative concentration for disinfectio n. There was no evidence of in vitro mutagenicity using Salmonella typhimur ium or sensitization or other adverse effect in a guinea pig model or in hu man subjects.