Acetophenone glycosides from thyme (Thymus vulgaris L.)

Authors
Wang, MF Kikuzaki, H Lin, CC Kahyaoglu, A Huang, MT Nakatani, N Ho, CT
Citation
Mf. Wang et al., Acetophenone glycosides from thyme (Thymus vulgaris L.), J AGR FOOD, 47(5), 1999, pp. 1911-1914
Citations number
22
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis
Journal title
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN journal
00218561 → ACNP
Volume
47
Issue
5
Year of publication
1999
Pages
1911 - 1914
Database
ISI
SICI code
0021-8561(199905)47:5<1911:AGFT(V>2.0.ZU;2-X
Abstract
Four acetophenone glycosides were isolated from the butanol-soluble fractio n of thyme extracts. Their structures were determined by spectral methods ( MS, NMR, and 2D-NMR). Among them, two new compounds, 4-hydroxyacetophenone 4-O-[5-O-(3,5-dimethoxy-4-hydroxybenzoyl)-beta-D-apiofuranosyl]-(1-->2)-bet a-D-glucopyranoside (1) and 4-hydroxyacetophenone 4-O-[5-O-(4-hydroxybenzoy l)-beta-D-apiofuranosyl]-(1-->2)-beta-D-glucopyranoside (2), were determine d. Compound 1 showed weak cytotoxicity, inhibiting DNA synthesis of human l eukemia cells.