CU,ZN-SUPEROXIDE DISMUTASE GENE DOSAGE AND CELL RESISTANCE TO OXIDATIVE STRESS - A REVIEW

It is well established that superoxide dismutase (SOD) is the irrespla ceable enzyme far aerobic lifestyle. Our understanding of its role has made strides recently as the result of gene transfection approach. Av ailable data on consequences of Cu,Zn-SOD gene transfection in cell re sistance to oxygen toxicity are reviewed. There are data that increasi ng only Cu,Zn-SOD can be toxic, and the balance between Cu,Zn-SOD and peroxide-removing enzymes is supposed to be of prime importance in the antioxidant defence. Role of Cu,Zn-SOD deregulation in carcinogenesis is discussed.