Effect of isoorientin isolated from Arum palaestinum on uterine smooth muscle of rats and guinea pigs

Citation
Fu. Afifi et al., Effect of isoorientin isolated from Arum palaestinum on uterine smooth muscle of rats and guinea pigs, J ETHNOPHAR, 65(2), 1999, pp. 173-177
Citations number
21
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JOURNAL OF ETHNOPHARMACOLOGY
ISSN journal
03788741 → ACNP
Volume
65
Issue
2
Year of publication
1999
Pages
173 - 177
Database
ISI
SICI code
0378-8741(199905)65:2<173:EOIIFA>2.0.ZU;2-J
Abstract
The phytochemical investigation of Arum palaestinum resulted in the isolati on of two flavone C-glucosides, namely isoorientin (luteolin 6-C-glucoside) and vitexin (apigenin 8-C glucoside). The effects of isoorientin on rat is olated aorta, ileum, trachea and uterus and on guinea-pig uterus were studi ed. Isoorientin (10(-7)M-6 x 10(-4)M) caused concentration-dependent inhibi tion of the amplitude and the frequency of the phasic contractions of the r at and guinea-pig uterus but did not affect the isolated aorta, ileum or tr achea. The results were discussed in relation to the effects of its aglycon e luteolin reported in the literature. (C) 1999 Elsevier Science Ireland Lt d. All rights reserved.