Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte

We have previously shown that interferon and tumor necrosis factor noncytop athically abolish hepatitis B virus (HBV) replication from the hepatocyte a nd kidney tubular epithelial cells in vivo. Here we show that a persistent lymphocytic choriomeningitis virus (LCMV) infection is cleared from the hep atocyte noncytopathically when the same cytokines are induced in the liver by antigen-nonspecific stimuli. These results indicate that, like HBV, LCMV is also susceptible to intracellular inactivation by cytokine-induced anti viral mechanisms that are operative in the hepatocyte. In contrast, LCMV is not cleared from intrahepatic nonparenchymal cells or splenocytes, indicat ing that, unlike the hepatocyte, these cells do not produce the factors req uired to inactivate LCMV. Antiviral mechanisms like these may have evolved to maintain the functional integrity of vital organs in the face of massive infection.