Cyclosphosphamide prednisone for combination immunosuppression and therapyof lymphoproliferative disease

Post-transplant lymphoproliferative disease (PTLD) is a well-known complica tion of solid organ transplantation. While this disorder can often be contr olled by decreasing immunosuppression, it is frequently difficult to contro l the resultant rejection. This case exemplifies this dilemma. To solve thi s problem, cyclosphosphamide (600 mg/m(2)) and prednisone (2 mg/kg times 5 days) were given every 3 weeks to simultaneously treat PTLD and provide imm unosuppression.