A general scheme for suppression of ABX strong coupling signals in heteronuclear scalar and dipolar correlation experiments

Enhanced versions of heteronuclear chemical shift correlation experiments w hich yield high-quality spectra with efficient suppression of extra peaks a rising from strong coupling effects are proposed. The enhanced pulse sequen ces feature properly designed filtering schemes inserted during preparation , or prior to acquisition, or at both places depending on the particular ex periment, These modifications extend the applicability of existing methods, since they exclude misinterpretation of spurious peaks and allow unambiguo us assignment of the desired correlations, The general applicability of the filtering method is noteworthy; both scalar- and dipolar-correlated experi ments with both X and H-1 detection using phase cycling or gradient pulses for coherence selection can be freed of strong coupling artifacts. (C) 1999 Academic Press.