Intermolecular trapping of acylpalladium and related acylmetal derivativeswith active C-H compounds

Authors
Negishi, E Liou, SY Xu, CD Shimoyama, I Makabe, H
Citation
E. Negishi et al., Intermolecular trapping of acylpalladium and related acylmetal derivativeswith active C-H compounds, J MOL CAT A, 143(1-3), 1999, pp. 279-286
Citations number
26
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
ISSN journal
13811169 → ACNP
Volume
143
Issue
1-3
Year of publication
1999
Pages
279 - 286
Database
ISI
SICI code
1381-1169(19990708)143:1-3<279:ITOAAR>2.0.ZU;2-7
Abstract
The reaction of aryl and alkenyl iodides and bromides with highly acidic ke tones in the presence of CO (40-45 atm), NEt3 (1-2 equiv.), and 5 mol% of C l2Pd(PPh3)(2) in DMF at 100 degrees C provides the corresponding enol carbo xylates formed via trapping of putative acylpalladiums with O-enolates. In cases where alkenyl halides are used, the initially formed products can cyc lize to give the corresponding lactones. (C) 1999 Elsevier Science B.V. All rights reserved.