New efficient nickel-catalyzed cross-coupling reaction between two Csp(3) centers

The presence of a remote unsaturation (double bond, carbonyl group, cyano g roup) in an alkyl halide facilitates its cross-coupling reaction with vario us diorganozincs in the presence of Ni(acac)(2) (7.5-10 mol % in THF/NMP mi xtures). These results were used to develop a new general cross-coupling re action between functionalized diorganozincs and alkyl iodides using m- or p -trifluoromethylstyrene as a reaction promotor and Ni(acac)(2) as a catalys t (7.5-10 mol %; -35 degrees C, 5-10 h) leading to a broad range of polyfun ctional cross-coupling products'.