R. Grigg et V. Sridharan, Palladium catalysed cascade cyclisation-anion capture, relay switches and molecular queues, J ORGMET CH, 576(1-2), 1999, pp. 65-87
Cyclic carbopalladation can be achieved by a group of related reactions tha
t provide versatile and powerful methodology for the construction of carboc
yclic and heterocyclic rings. These ring forming processes are marked by th
eir tolerance of a wide range of functionality together with their ability
to process a variety of starter species and to effect cyclisation onto all
types of C-C unsaturated bonds. Substantial additional pre- and post-cyclis
ation functionality can be incorporated via cyclisation-anion capture and/o
r polycomponent cascades that switch between inter- and intra-molecular pro
cesses. The polycomponent cascades can be regarded as proceeding via molecu
lar queuing processes and when gaseous reactants are employed the queuing p
rocesses are sensitive to pressure. These wide ranging processes occur with
excellent chemo-, regio- and stereo-selectivity and allow incorporation of
precisely located complex functionality whilst generating bridged, fused a
nd spirocyclic systems and multiple C-C/C-heteroatom bonds. (C) 1999 Elsevi
er Science S.A. All rights reserved.