Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase beta

Authors
Deng, JZ Sun, DA Starck, SR Hecht, SM Cerny, RL Engen, JR
Citation
Jz. Deng et al., Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase beta, J CHEM S P1, (9), 1999, pp. 1147-1149
Citations number
35
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
0300922X → ACNP
Issue
9
Year of publication
1999
Pages
1147 - 1149
Database
ISI
SICI code
0300-922X(19990507):9<1147:CAANDQ>2.0.ZU;2-T
Abstract
Chrysochlamic acid (1), a new DNA polymerase beta inhibitor having an IC50 of 4.3 mu M, has been isolated from Chrysochlamys ulei through bioassay-gui ded fractionation; it is the first example of a prenyl m-methylhydroquinone occurring in a higher terrestrial plant.