Interaction between amphotericin B and sterols in monolayers. Mixed Films of ergosterol-amphotericin B

Analysis of the compression isotherms of ergosterol/amphotericin B (AmB) mi xed monolayers spread on aqueous substrates shows the existence of interact ions between the two components at AmB mole fractions between 0.1 and 0.7. At low surface pressure AmB molecules appear to lie horizontally in the A/W interface and ergosterol molecules to stand vertically, while at higher su rface pressures the molecules of both components are vertically oriented at the interface.