This paper presents epidemiological, laboratory, and clinical data on 12 ye
ars of dengue virus activity in the Stare of Rio de Janeiro from the time t
he disease was first confirmed virologically in April 1986 through April 19
98. DEN-1 and DEN-2 viruses are the serotypes circulating in the state and
were responsible for the epidemics reported during the last 12 years. The r
esults published here show both the impact of dengue virus infections on th
e population and laboratory advances that have improved dengue diagnosis.