Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice

Authors
Brady, LS Herkenham, M Rothman, RB Partilla, JS Konig, M Zimmer, AM Zimmer, A
Citation
Ls. Brady et al., Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice, MOL BRAIN R, 68(1-2), 1999, pp. 193-197
Citations number
22
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR BRAIN RESEARCH
ISSN journal
0169328X → ACNP
Volume
68
Issue
1-2
Year of publication
1999
Pages
193 - 197
Database
ISI
SICI code
0169-328X(19990507)68:1-2<193:RUOORB>2.0.ZU;2-C
Abstract
Mn and delta opioid receptors were labeled in enkephalin knockout mice by q uantitative autoradiography. Discrete, large increases (100-300%) were foun d in limbic forebrain structures for mu binding and striatum and pallidum f or delta binding. The up-regulation of opioid receptors may reflect a form of 'denervation supersensitivity.' The receptor up-regulation in limbic are as is consistent with the increased emotional and aggressive behaviors obse rved in the enkephalin knockout mice. (C) 1999 Elsevier Science B.V. All ri ghts reserved.