IN-VITRO EVALUATION OF FLUTAMIDE-CARRIER SYSTEMS .1. PREPARATION AND EVALUATION OF FLUTAMIDE SYSTEMS WITH POLYVINYL PYRROLIDONE AND POLYETHYLENE-GLYCOL-4000 AND POLYETHYLENE-GLYCOL-6000

Authors
ADEL MS GENEIDI AS SHOUKRI RA SAAD I
Citation
Ms. Adel et al., IN-VITRO EVALUATION OF FLUTAMIDE-CARRIER SYSTEMS .1. PREPARATION AND EVALUATION OF FLUTAMIDE SYSTEMS WITH POLYVINYL PYRROLIDONE AND POLYETHYLENE-GLYCOL-4000 AND POLYETHYLENE-GLYCOL-6000, Die Pharmazie, 52(5), 1997, pp. 373-375
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
52
Issue
5
Year of publication
1997
Pages
373 - 375
Database
ISI
SICI code
0031-7144(1997)52:5<373:IEOFS.>2.0.ZU;2-J
Abstract
Coprecipitates were prepared using different ratios of flutamide with polyvinyl pyrrolidine (PVP), polyethylene glycol (PEG) 4000 and 6000. Drug solubility in carrier solutions, thin layer chromatography (TLC), differential scanning calorimetry (DSC), infra-red spectroscopy (IR), uniformity of drug content, drug dissolution from its respective syst ems and effect of aging on the physico-chemical parameters of stored f lutamide-polymer system were studied. PEG 6000 was found to be the mos t efficient polymer in increasing both the solubility and the release rate of flutamide. Interaction was found to be complete in certain rat ios of drug/polymer systems. The dissolution pattern of flutamide from all the pre pared systems appeared to fit a first order mechanism. Ph ysico-chemical parameters of flutamide/carrier systems were not influe nced by storage.