G. Blazso et al., ANTIINFLAMMATORY ACTIVITIES OF PROCYANIDIN-CONTAINING EXTRACTS FROM PINUS-PINASTER AIT AFTER ORAL AND CUTANEOUS APPLICATION, Die Pharmazie, 52(5), 1997, pp. 380-382
Orally in liquid diet administered procyanidin-containing extracts fro
m Pinus pinaster Ait. decreased the croton oil-induced ear edema in mi
ce or the compound 48/80-induced hind paw edema in rats to a statistic
ally significant extent. Most effective were the extracts containing m
ainly oligomeric procyanidins with chain lengths greater then 4 units
(extracts A or B). Further, the different extracts incorporated in var
ious concentrations (1.0, 3.0 or 0.1%) in 5% hydroxyethylcellulose gel
and applied topically on the shaved back of rats, inhibited significa
ntly the ultraviolet radiation-induced increased capillary permeabilit
y. In these experiments, normalisation of capillary permeability was n
ot correlated with the content of the extracts on higher oligomeric pr
ocyanidins.