Activation of the Bcl-2 promoter by nerve growth factor is mediated by thep42/p44 MAPK cascade

Authors
Liu, YZ Boxer, LM Latchman, DS
Citation
Yz. Liu et al., Activation of the Bcl-2 promoter by nerve growth factor is mediated by thep42/p44 MAPK cascade, NUCL ACID R, 27(10), 1999, pp. 2086-2090
Citations number
43
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEIC ACIDS RESEARCH
ISSN journal
03051048 → ACNP
Volume
27
Issue
10
Year of publication
1999
Pages
2086 - 2090
Database
ISI
SICI code
0305-1048(19990515)27:10<2086:AOTBPB>2.0.ZU;2-2
Abstract
The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell t ypes. We show for the first time that the Bcl-2 promoter is activated by th e neuronal survival factor nerve growth factor (NGF) and that this effect i s dependent on a region of the promoter from -1472 to -1414. This activatio n requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but i s independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.