Magnetic resonance imaging (MRI) as a method to investigate movement of water during the extrusion of pastes

Citation
G. Tomer et al., Magnetic resonance imaging (MRI) as a method to investigate movement of water during the extrusion of pastes, PHARM RES, 16(5), 1999, pp. 666-671
Citations number
18
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMACEUTICAL RESEARCH
ISSN journal
07248741 → ACNP
Volume
16
Issue
5
Year of publication
1999
Pages
666 - 671
Database
ISI
SICI code
0724-8741(199905)16:5<666:MRI(AA>2.0.ZU;2-1
Abstract
Purpose. To assess the potential of Magnetic Resonance Imaging (MRI) as a m ethod of detecting water movement during the extrusion of pastes. Methods. Plug samples were made from mixtures of model materials and microc rystalline cellulose with two water contents at two different ram speeds to simulate ram extrusion. The extrusion process was stopped at different sta ges and analyzed for water distribution using MRI to assess the influence o f water content and the speed of ram on water movement as the extrusion pro cess progresses. Results. Two types of water movement were detected: vertical and radial. Wh en extruding at the faster ram speed, water moved predominantly in the vert ical direction, whereas when extruding at a slower ram speed it moved predo minantly in the radial direction. At the beginning of the extrusion process a greater water movement in the wetter formulations was observed. Conclusions. MRI appears to be a useful approach to non-invasive water mapp ing, and is expected to contribute towards a greater understanding of the r ole of water in the extrusion of pastes.