Transcellular uptake mechanisms of the intestinal epithelial barrier - Part one

Authors
Daugherty, AL Mrsny, RJ
Citation
Al. Daugherty et Rj. Mrsny, Transcellular uptake mechanisms of the intestinal epithelial barrier - Part one, PHARM SCI T, 2(4), 1999, pp. 144-151
Citations number
66
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY
ISSN journal
14615347 → ACNP
Volume
2
Issue
4
Year of publication
1999
Pages
144 - 151
Database
ISI
SICI code
1461-5347(199904)2:4<144:TUMOTI>2.0.ZU;2-1
Abstract
Part one of this two-part review addresses the transport of therapeutics ac ross the intestinal barrier, and focuses on transcellular transport through the intestinal epithelia. The anatomical, biochemical and physiological pa rameters impacting transcellular uptake of orally administered drugs are de scribed, and methods for overcoming obstacles limiting successful transcell ular oral drug delivery are discussed. Part two will cover paracellular tra nsport.