PROTEIN MIMETICS (TASP) BY SEQUENTIAL CONDENSATION OF PEPTIDE LOOPS TO AN IMMOBILIZED TOPOLOGICAL TEMPLATE

Authors
PELUSO S DUMY P EGGLESTON IM GARROUSTE P MUTTER M
Citation
S. Peluso et al., PROTEIN MIMETICS (TASP) BY SEQUENTIAL CONDENSATION OF PEPTIDE LOOPS TO AN IMMOBILIZED TOPOLOGICAL TEMPLATE, Tetrahedron, 53(21), 1997, pp. 7231-7236
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
21
Year of publication
1997
Pages
7231 - 7236
Database
ISI
SICI code
0040-4020(1997)53:21<7231:PM(BSC>2.0.ZU;2-#
Abstract
The sequential condensation of peptide loops onto selectively addressa ble templates immobilised on solid supports allows the rapid and effic ient synthesis of protein mimetics applying the TASP (Template Assembl ed Synthetic Protein) concept. As an example of the versatility of thi s methodology, we describe here the solid phase assembly of a represen tative 3-loop receptor mimetic. (C) 1997 Elsevier Science Ltd.