Lignans and coumarins metabolites from Melicope hayesii

Two novel compounds, the lignan, (+)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydro xyphenyl)-3,7-dioxabicyclo [3,3,0]octane, and the coumarin, (+)-7-(3-methyl -4-carboxybutanoxy)umbelliferone methyl ester, have been isolated from the aerial parts of Melicope hayesii. The known compounds, eudesmin, kobusin, N -p-coumaroyltyramine, N-methyl-2-pyrrolidinone, umbelliferone and 7-(3-meth ylbut-2-enoxy)umbelliferone were also obtained. Their structures were deter mined by extensive NMR studies. (C) 1999 Elsevier Science Ltd. All rights r eserved.