Inhibitory effects of Ougi-keishi-gomotsu-to, a traditional herbal medicine, on lipid peroxidation and protein oxidative modification of mouse brain homogenate induced by copper

Ougi-Keishi-gomotsu-to a traditional herbal medicine, is used clinically fo r patients with abnormal sensations and pain in the legs in neuropathy. It was shown to have inhibitory effects on lipid peroxidation and protein oxid ative modification of brain homogenate induced by copper. Its effect was st ronger than those of mannitol and cu-tocopherol as free radical scavenger a nd antioxidant. These results demonstrated that Ougi-keishi-gomotsu-to has antioxidative effects on neuron injury derived from oxidative stress induce d by metal. Copyright (C) 1999 John Whey & Sons, Ltd.