STEREOSELECTIVE AMINATION OF CHIRAL ENOLATES - SYNTHESIS OF ENANTIOMERICALLY PURE ALPHA,BETA-DIAMINO ACIDS, CHIRAL KEY COMPOUNDS IN THE SYNTHESIS OF CONFORMATIONALLY CONSTRAINED PEPTIDOMIMETRICS AND NON-PEPTIDOMIMETICS

This work describes an efficient synthesis of enantiomerically pure (R )-2-aminomethylalanine, (R)-2-aminomethylnorvaline, (R)-2-aminomethylv aline, (R)-2-aminomethylleucine and (R)-2-aminomethylphenylalanine by electrophilic amination of chiral 2-cyanoesters with O-(diphenylphosph inyl)hydroxylamine followed by appropiate reduction and hydrolysis.