A direct in vivo approach for skin gene therapy

In vivo gene therapy is a direct and effective way to express genes in the epidermis. Plasmid DNA that contains the desired gene can be injected intra dermally, and it is rapidly absorbed and expressed by the epidermis. Becaus e gene expression following plasmid injection is transient, the two princip al therapeutic uses of this approach are genetic immunization and the expre ssion of biological response modifiers to treat skin disease.