Aa. Bankier et al., Pulmonary emphysema: Subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry, RADIOLOGY, 211(3), 1999, pp. 851-858
Citations number
30
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
PURPOSE: To compare subjective visual grading of pulmonary emphysema with m
acroscopic morphometry and computed tomographic (CT) densitometry.
MATERIALS AND METHODS: In 62 consecutive patients who underwent thin-sectio
n CT before surgical lung resection, emphysema was objectively quantified w
ith computer-assisted macroscopic morphometry and CT densitometry. The perc
entage of lung macroscopically occupied by emphysema was compared with the
percentage occupied on CT scans by pixels with attenuation values lower tha
n a predefined threshold (CT densitome), Three readers with varying degrees
of expertise subjectively graded emphysema with visual assessment at two r
eading sessions. Data from objective quantification and subjective grading
were analyzed with correlation coefficients, and interobserver and intraobs
erver agreement were calculated.
RESULTS: Subjective grading of emphysema showed less agreement with the mac
roscopic reference standard results (r = 0.439-0.505; P <.05) than with obj
ective CT densitometric results (r = 0.555-0.623; P < .001). The 95% Cls fo
r the intercepts of the linear regression lines were suggestive of systemat
ic subjective overestimation of;emphysema by all three readers. lnterobseve
r agrement was moderate (K = 0.431-0.589). Intraobserver agreement was good
to excellent (K = 0.738-0.936). The expertise of individual readers did no
t substantially influence results.
CONCLUSION: Systematic overestimation and moderate interobserver agreement
may compromise subjective visual grading of emphysema, which suggests that
subjective visual grading should be supplemented with objective methods to
achieve precise, reader-independent quantification of emphysema.