Helicobacter pylori virulence and genetic geography

Authors
Covacci, A Telford, JL Del Giudice, G Parsonnet, J Rappuoli, R
Citation
A. Covacci et al., Helicobacter pylori virulence and genetic geography, SCIENCE, 284(5418), 1999, pp. 1328-1333
Citations number
92
Categorie Soggetti
Multidisciplinary,Multidisciplinary,Multidisciplinary
Journal title
SCIENCE
ISSN journal
00368075 → ACNP
Volume
284
Issue
5418
Year of publication
1999
Pages
1328 - 1333
Database
ISI
SICI code
0036-8075(19990521)284:5418<1328:HPVAGG>2.0.ZU;2-L
Abstract
Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A p athogenicity island acquired by horizontal transfer, coding for a type IV s ecretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic d istribution suggests coevolution of man and Helicobacter pylori.